UTRN CLIA Kit for Human(Homo sapiens) | EIAab.comUTRN CLIA Kit for Human(Homo sapiens)

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Index > Protein center > UTRN(Gene name) > Human

UTRN (Gene name),

Utrophin (Protein name ), UTRO_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

UTRN(DMDL;DRP1);

Protein name:

Utrophin;

Alternative:

Dystrophin-related protein 1(DRP-1);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with the syntrophins SNTA1; SNTB1 and SNTB2. Interacts with SYNM. Interacts (via its WWW and ZZ domains) with DAG1 (via the PPXY motif of betaDAG1); the interaction is inhibited by the tyrosine phosphorylation of the PPXY motif of DAG1.

Function:

May play a role in anchoring the cytoskeleton to the plasma membrane.

Subcellular Location:

Cell junction synapse postsynaptic cell membrane Peripheral membrane protein Cytoplasmic side Cytoplasm cytoskeleton Neuromuscular junction.

Protein Attributes:

Sequence length:

3433

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PHDTSTDLTE | VMEQIHSTFP | SCCPNVPSRP | QAM

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000356515

Pfam:

PF00307

UniGene:

Hs.133135

String:

P46939

MIM:

128240

SMR:

P46939

KEGG:

hsa:7402

Uniprot:

P46939

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ELISA Kit for Human Utrophin

Cat.:

E7872h

Price:

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Manual:

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MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human Utrophin

Cat.:

U7872h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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Polyclonal Antibody for Human Utrophin

Cat.:

P7872Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Utrophin

Protein for Human Utrophin

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Primary structure of dystrophin-related protein."
Tinsley J.M. , Blake D.J. , Roche A. , Fairbrother U. , Riss J. , Byth B.C. , Knight A.E. , Kendrick-Jones J. , Suthers G.K. , Love D.R. , Edwards Y.H. , Davies K.E.
Nature360:591-593(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"Up71 and up140, two novel transcripts of utrophin that are homologues of short forms of dystrophin."
Wilson J. , Putt W. , Jimenez C. , Edwards Y.H.
Hum. Mol. Genet.8:1271-1278(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS UP71 AND UP140);ALTERNATIVE PROMOTER USAGE;TISSUE SPECIFICITY
3.

"The DNA sequence and analysis of human chromosome 6."
Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"A second promoter provides an alternative target for therapeutic up-regulation of utrophin in Duchenne muscular dystrophy."
Burton E.A. , Tinsley J.M. , Holzfeind P.J. , Rodrigues N.R. , Davies K.E.
Proc. Natl. Acad. Sci. U.S.A.96:14025-14030(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-31 (ISOFORM 2);ALTERNATIVE PROMOTER USAGE
5.

"Syntrophin binds to an alternatively spliced exon of dystrophin."
Ahn A.H. , Kunkel L.M.
J. Cell Biol.128:363-371(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SNTB1
6.

"The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relatives."
Ahn A.H. , Feener C.A. , Gussoni E. , Yoshida M. , Ozawa E. , Kunkel L.M.
J. Biol. Chem.271:2724-2730(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SNTA1 AND SNTB2
7.

"Contribution of the different modules in the utrophin carboxy-terminal region to the formation and regulation of the DAP complex."
Tommasi di Vignano A. , Di Zenzo G. , Sudol M. , Cesareni G. , Dente L.
FEBS Lett.471:229-234(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DAG1
8.

"Adhesion-dependent tyrosine phosphorylation of (beta)-dystroglycan regulates its interaction with utrophin."
James M. , Nuttall A. , Ilsley J.L. , Ottersbach K. , Tinsley J.M. , Sudol M. , Winder S.J.
J. Cell Sci.113:1717-1726(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DAG1
9.

"Interactions of intermediate filament protein synemin with dystrophin and utrophin."
Bhosle R.C. , Michele D.E. , Campbell K.P. , Li Z. , Robson R.M.
Biochem. Biophys. Res. Commun.346:768-777(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SYNM
10.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-295;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
11.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-4; SER-10 AND SER-3297;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
12.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
13.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
14.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.

"The actin binding affinity of the utrophin tandem calponin-homology domain is primarily determined by its N-terminal domain."
Singh S.M. , Bandi S. , Winder S.J. , Mallela K.M.
Biochemistry53:1801-1809(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOMAIN CH;ACTIN-BINDING
16.

"The 2.0-A structure of the second calponin homology domain from the actin-binding region of the dystrophin homologue utrophin."
Keep N.H. , Norwood F.L.M. , Moores C.A. , Winder S.J. , Kendrick-Jones J.
J. Mol. Biol.285:1257-1264(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 144-261
17.

"Crystal structure of the actin-binding region of utrophin reveals a head-to-tail dimer."
Keep N.H. , Winder S.J. , Moores C.A. , Walke S. , Norwood F.L.M. , Kendrick-Jones J.
Structure7:1539-1546(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 31-256;SUBUNIT
18.

"Structure of the utrophin actin-binding domain bound to F-actin reveals binding by an induced fit mechanism."
Moores C.A. , Keep N.H. , Kendrick-Jones J.
J. Mol. Biol.297:465-480(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CRYO-ELECTRON MICROSCOPY (20 ANGSTROMS);ACTIN-BINDING

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